Teaching in population pharmacometrics
 
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Some recent advances in covariate modeling methodology by the Uppsala Pharmacometric Research Group

 
 

Authors

Title

Reference

Åsa Johansson and Mats O Karlsson

Multiple imputation of missing covariates in NONMEM and evaluation of its sensitivity to η-shrinkage

WCoP 2012

Vijay Ivaturi, Ron Keizer and Mats O. Karlsson

A full random effects model for characterising covariate relations

WCoP 2012

Andrew C. Hooker and Mats O. Karlsson

The Kaplan-Meier Mean Covariate plot (KMMC): a new diagnostic for covariates in time-to-event models.

PAGE 2012

Takayuki Katsube, Akash Khandelwal, Andrew C Hooker, E. Niclas Jonsson, Mats O Karlsson

Characterization of Stepwise Covariate Model Building Combined with Cross-Validation

PAGE 2012

Mats O Karlsson

A full model approach based on the covariance matrix of parameters and covariates

PAGE 2012

Khandelwal A, Harling K, Jonsson EN, Hooker AC, Karlsson MO.

A fast method for testing covariates in population PK/PD Models.

AAPS J. 2011 ;13:464-72.

Bergstrand M, Hooker AC, Wallin JE, Karlsson MO.

Prediction-corrected visual predictive checks for diagnosing nonlinear mixed-effects models.

AAPS J. 2011 ;13:143-51.

Paul G. Baverel, Radojka M. Savic, Scott F. Marshall, Mats O. Karlsson

A novel covariate search method intended for PKPD models with nonparametric parameter distributions

PAGE 2011

Takayuki Katsube, Akash Khandelwal, Kajsa Harling, Andrew C Hooker, Mats O Karlsson

Evaluation of Stepwise Covariate Model Building Combined with Cross-Validation

PAGE 2011

Ron J Keizer, Akash Khandelwal, Andrew C Hooker, Mats O Karlsson

The bootstrap of Stepwise Covariate Modeling using linear approximations

PAGE 2011

Akash Khandelwal, Andrew C Hooker, and Mats O Karlsson

Influence of Correlated Covariates on Predictive Performance for Different Models

PAGE 2011

Vijay D Ivaturi, Andrew C Hooker, Mats O Karlsson

Selection Bias in Pre-Specified Covariate Models

PAGE 2011

Åsa M. Johansson, Mats O. Karlsson

Comparison of methods for handling missing covariate data

PAGE 2011

Akash Khandelwal, Kajsa Harling, E Niclas Jonsson, Andrew C Hooker, Mats O Karlsson

Covariate Model Building Using Linear Approximations

PAGE 2010

Savic RM, Karlsson MO.

Importance of shrinkage in empirical bayes estimates for diagnostics: problems and solutions.

AAPS J. 2009 ;11:558-69.