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Covariate Model Building and Evaluation in NONMEM
(A NONMEM Workshop for intermediate and advanced users)

Glasgow, Scotland, June 10-11, 2013
(Prior to the
PAGE meeting)


The Uppsala Pharmacometrics Group and is happy to announce a NONMEM Workshop on Covariate Model Building and Evaluation tailored for Intermediate and Advanced NONMEM users. The course will present modeling strategies, techniques and implementations for the handling of covariate information in population models. Traditional methods will be complemented with recent advances in covariate model building methodology and diagnostics for more efficient, robust and informed covariate models. Such new functionality particularly related to covariate modeling has been introduced in recent updates to PsN and Xpose4. Advantages and disadvantages of the different covariate model building methods will be presented and the relationship between modeling aim, data and suitable method discussed. Methods for handling missing covariates, special considerations for handling time-varying covariates and covariates measured with error will be presented.

The course will consist of both lectures and hands-on computer exercises using NONMEM 7.2, PsN and Xpose 4. Self-instructive material is provided for further studies and exploration of additional examples within the field.

The Uppsala group has been involved in developing pharmacometric models and methodology for over twenty years and has extensive experience in development of covariate models and covariate model building methodology. In parallel, model building procedures and informative diagnostics for covariate model building and covariate model evaluation have been developed, evaluated and integrated into the user-friendly software Perl-speaks-NONMEM (PsN)  and Xpose 4.


Prof Mats Karlsson

Practical Information

The course will run June 10-11, 2013 (8:30 am - 5:30 pm).

Computer hardware/software - The course will include hands-on training, with the participants working on their own computers.  All programs will run from a USB memory-stick and participants will not be required to install any programs on their computer. All participants must bring their own Windows laptops.

Course Fee

Regular fee: €1,200
Student/Post-doc fee: €800

Registration fee includes: extensive electronic material including lectures, exercises, programs (PsN and Xpose), additional self-study material including hands-on's and solutions. Morning and afternoon refreshments and lunches are included as well as a reception on June 10 after the first course day.

To register

Please fill out this form and e-mail to UppsalaPharmacometrics. Payment information will then be sent to you.

Registration is not complete until payment is received.

Cancellation: Refunds will be provided on or before June 1, 2013. Registrants are welcome to swap their place with another person at any time.


For questions, please e-mail UppsalaPharmacometrics.